Homologous recombination
| PAG Title | Homologous recombination |
| PAG ID | WIG000542 |
| Type | P |
| Source Link |  MSigDB |
| Publication Reference | NA |
| PAG Description | Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. |
| Species | Homo sapiens |
| nCoCo Score | 3,866 |
| Base PAG ID | WIG000542 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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